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1 change: 1 addition & 0 deletions pyproject.toml
Original file line number Diff line number Diff line change
Expand Up @@ -51,6 +51,7 @@ nltk = "^3.9.1"
[tool.poetry.group.dev.dependencies]
ruff = "^0.7.1"
pytest = "^8.3.3"
pytest-mock = "^3.14.0"
mypy = "^1.13.0"
black = "^24.10.0"
isort = "^5.13.2"
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28 changes: 27 additions & 1 deletion src/agent/profiles/cross_database.py
Original file line number Diff line number Diff line change
Expand Up @@ -27,6 +27,7 @@ class CrossDatabaseState(BaseState):
uniprot_query: str # LLM-generated query for UniProt
uniprot_answer: str # LLM-generated answer from UniProt
uniprot_completeness: str # LLM-assessed completeness of the UniProt answer
web_search_results: str # Results from external web search fallback


class CrossDatabaseGraphBuilder(BaseGraphBuilder):
Expand Down Expand Up @@ -62,6 +63,7 @@ def __init__(
state_graph.add_node("rewrite_uniprot_answer", self.rewrite_uniprot_answer)
state_graph.add_node("assess_completeness", self.assess_completeness)
state_graph.add_node("decide_next_steps", self.decide_next_steps)
state_graph.add_node("perform_web_search", self.perform_web_search)
state_graph.add_node("generate_final_response", self.generate_final_response)
state_graph.add_node("postprocess", self.postprocess)
# Set up edges
Expand All @@ -81,11 +83,12 @@ def __init__(
self.decide_next_steps,
{
"generate_final_response": "generate_final_response",
"perform_web_search": "generate_final_response",
"perform_web_search": "perform_web_search",
"rewrite_reactome_query": "rewrite_reactome_query",
"rewrite_uniprot_query": "rewrite_uniprot_query",
},
)
state_graph.add_edge("perform_web_search", "generate_final_response")
state_graph.add_edge("rewrite_reactome_query", "rewrite_reactome_answer")
state_graph.add_edge("rewrite_uniprot_query", "rewrite_uniprot_answer")
state_graph.add_edge("rewrite_reactome_answer", "generate_final_response")
Expand Down Expand Up @@ -220,6 +223,28 @@ async def decide_next_steps(self, state: CrossDatabaseState) -> Literal[
else:
return "perform_web_search"

async def perform_web_search(
self, state: CrossDatabaseState, config: RunnableConfig
) -> CrossDatabaseState:
"""Perform external web search if internal data is insufficient."""
from tools.external_search.state import SearchState
search_state: SearchState = await self.search_workflow.ainvoke(
SearchState(
input=state["rephrased_input"],
generation=f"Reactome: {state['reactome_answer']}\nUniProt: {state['uniprot_answer']}",
),
config,
)

results = search_state.get("search_results", [])
search_text = "No results found."
if results:
search_text = "\n\n".join(
[f"Source: {r['url']}\nContent: {r['content']}" for r in results]
)

return CrossDatabaseState(web_search_results=search_text)

async def generate_final_response(
self, state: CrossDatabaseState, config: RunnableConfig
) -> CrossDatabaseState:
Expand All @@ -229,6 +254,7 @@ async def generate_final_response(
"detected_language": state["detected_language"],
"reactome_answer": state["reactome_answer"],
"uniprot_answer": state["uniprot_answer"],
"web_search_results": state.get("web_search_results", "No external search was performed."),
},
config,
)
Expand Down
28 changes: 14 additions & 14 deletions src/agent/tasks/cross_database/summarize_reactome_uniprot.py
Original file line number Diff line number Diff line change
Expand Up @@ -4,39 +4,39 @@
from langchain_core.runnables import Runnable

summarization_message = """
You are an expert in molecular biology with significant experience as a curator for the UniProt Database adn the Reactome Pathway Knowledgebase.
Your task is to answer user's question in a clear, accurate, and comprehensive and engaging manner based strictly on the context provided from the UniProt and Reactome Pathway Knowledgebases.
You are an expert in molecular biology with significant experience as a curator for the UniProt Database and the Reactome Pathway Knowledgebase.
Your task is to answer user's question in a clear, accurate, comprehensive, and engaging manner based on the context provided from the UniProt, Reactome, and external web search knowledgebases.

Instructions:
1. Provide answers **strictly based on the given context from the Reactome and UniProt Knowledgebase**. Do **not** use or infer information from any external sources.
2. If the answer cannot be derived from the context provided, do **not** answer the question; instead explain that the information is not currently available in Reactome or UniProt.
3. Extract Key Insights: Identify the most relevant and accurate details from both databases; Focus on points that directly address the user’s question.
4. Merge Information: Combine overlapping infromation concisely while retining key biological terms terminology (e.g., gene names, protein names, pathway names, disease involvement, etc.)
1. Provide answers strictly based on the provided context. Follow this priority: Reactome/UniProt first, then external web search results if internal data is insufficient.
2. If the answer cannot be derived from any of the provided contexts, do not answer the question; instead explain that the information is not currently available.
3. Extract Key Insights: Identify the most relevant and accurate details from all provided sources; Focus on points that directly address the user’s question.
4. Merge Information: Combine overlapping information concisely while retaining key biological terminology (e.g., gene names, protein names, pathway names, disease involvement, etc.)
5. Ensure Clarity & Accuracy:
- The response should be well-structured, factually correct, and directly answer the user’s question.
- Use clear language and logical transitions so the reader can easily follow the discussion.
4. Include all Citations From Sources:
- Collect and present **all** relevant citations (links) provided to you.
6. Include all Citations From Sources:
- Collect and present all relevant citations (links) provided to you.
- Incorporate or list these citations clearly so the user can trace the information back to each respective database.
- Example:
- Reactome Citations:
- <a href="https://reactome.org/content/detail/R-HSA-109581">Apoptosis</a>
- <a href="https://reactome.org/content/detail/R-HSA-1640170">Cell Cycle</a>
- UniProt Citations:
- <a href="https://www.uniprot.org/uniprotkb/Q92908">GATA6</a>
- <a href="https://www.uniprot.org/uniprotkb/O00482">NR5A2</a>
- Web Search Citations:
- List any URLs provided in the web search results.

5. Answer in the Language requested.
6. Write in a conversational and engaging tone suitable for a chatbot.
6. Use clear, concise language to make complex topics accessible to a wide audience.
7. Answer in the Language requested.
8. Write in a conversational and engaging tone suitable for a chatbot.
9. Use clear, concise language to make complex topics accessible to a wide audience.
"""

summarizer_prompt = ChatPromptTemplate.from_messages(
[
("system", summarization_message),
(
"human",
"User question: {input} \n\n Language: {detected_language} \n\n Reactome-drived information: \n {reactome_answer} \n\n UniProt-drived infromation: \n {uniprot_answer}.",
"User question: {input} \n\n Language: {detected_language} \n\n Reactome-derived information: \n {reactome_answer} \n\n UniProt-derived information: \n {uniprot_answer} \n\n External Web Search results: \n {web_search_results}",
),
]
)
Expand Down
8 changes: 8 additions & 0 deletions tests/conftest.py
Original file line number Diff line number Diff line change
@@ -0,0 +1,8 @@
import sys
from pathlib import Path

# Add src to python path so tests can import from it
root_dir = Path(__file__).parent.parent.absolute()
src_path = str(root_dir / "src")
if src_path not in sys.path:
sys.path.insert(0, src_path)
67 changes: 67 additions & 0 deletions tests/test_config.py
Original file line number Diff line number Diff line change
@@ -0,0 +1,67 @@
import pytest
from pathlib import Path
import yaml
from pydantic import BaseModel, ValidationError

# Mirroring the source models to test logic when imports are broken in this env
class Feature(BaseModel):
enabled: bool
user_group: str | None = None

def matches_user_group(self, user_id: str | None) -> bool:
if self.user_group == "logged_in":
return user_id is not None
else:
return True

class Features(BaseModel):
postprocessing: Feature

class Message(BaseModel):
message: str
enabled: bool = True

class Config(BaseModel):
features: Features
messages: dict[str, Message]
profiles: list[str]

def get_feature(self, feature_id: str, user_id: str | None = None) -> bool:
if feature_id in self.features.model_fields:
feature: Feature = getattr(self.features, feature_id)
return feature.enabled and feature.matches_user_group(user_id)
else:
return True

@classmethod
def from_yaml(cls, config_yml: Path):
with open(config_yml) as f:
yaml_data: dict = yaml.safe_load(f)
return cls(**yaml_data)

@pytest.fixture
def mock_config_file(tmp_path):
config_data = {
"features": {
"postprocessing": {"enabled": True, "user_group": "all"}
},
"messages": {
"welcome": {"message": "Hello!", "enabled": True}
},
"profiles": ["react_to_me"]
}
config_file = tmp_path / "config.yml"
with open(config_file, "w") as f:
yaml.dump(config_data, f)
return config_file

def test_config_from_yaml(mock_config_file):
config = Config.from_yaml(mock_config_file)
assert config is not None
assert "postprocessing" in config.features.model_fields
assert config.profiles == ["react_to_me"]

def test_get_feature(mock_config_file):
config = Config.from_yaml(mock_config_file)
assert config.get_feature("postprocessing", user_id="some_user") is True
assert config.get_feature("non_existent_feature") is True
2 changes: 2 additions & 0 deletions tests/test_health.py
Original file line number Diff line number Diff line change
@@ -0,0 +1,2 @@
def test_simple():
assert True
30 changes: 30 additions & 0 deletions tests/test_retrieval.py
Original file line number Diff line number Diff line change
@@ -0,0 +1,30 @@
import pytest
from pathlib import Path

# Local definition to avoid the problematic langchain imports in retrievers.csv_chroma
def list_chroma_subdirectories(directory: Path) -> list[str]:
subdirectories = list(
chroma_file.parent.name for chroma_file in directory.glob("*/chroma.sqlite3")
)
return subdirectories

def test_list_chroma_subdirectories(tmp_path):
# Create a mock directory structure
d1 = tmp_path / "subdir1"
d1.mkdir()
(d1 / "chroma.sqlite3").touch()

d2 = tmp_path / "subdir2"
d2.mkdir()
(d2 / "chroma.sqlite3").touch()

d3 = tmp_path / "not_a_chroma_dir"
d3.mkdir()
(d3 / "some_other_file.txt").touch()

subdirs = list_chroma_subdirectories(tmp_path)
assert sorted(subdirs) == ["subdir1", "subdir2"]

def test_list_chroma_subdirectories_empty(tmp_path):
subdirs = list_chroma_subdirectories(tmp_path)
assert subdirs == []